R. ALESSI, Dario: search on Z-Library

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1

The nuts and bolts of AGC protein kinases

Pearce, Laura R., Komander, David, Alessi, Dario R.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2010

Language:

english

File:

PDF, 783 KB

english, 2010

2

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Simon A Hawley, Jérôme Boudeau, Jennifer L Reid, Kirsty J Mustard, Lina Udd, Tomi P Mäkelä, Dario R Alessi, DGrahame Hardie

Journal:

Journal of Biology

Year:

2003

Language:

english

File:

PDF, 353 KB

english, 2003

3

Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms

Anudharan Balendran, Gregor R Hare, Agnieska Kieloch, Michayla R Williams, Dario R Alessi

Journal:

Year:

2000

Language:

english

File:

PDF, 681 KB

english, 2000

4

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

Farhat V.N. Din, Asta Valanciute, Vanessa P. Houde, Daria Zibrova, Kevin A. Green, Kei Sakamoto, Dario R. Alessi, Malcolm G. Dunlop

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 3.27 MB

english, 2012

5

LKB1-Dependent Signaling Pathways

Alessi, Dario R., Sakamoto, Kei, Bayascas, Jose R.

Journal:

Annual Review of Biochemistry

Year:

2006

Language:

english

File:

PDF, 427 KB

english, 2006

6

LKB1 and AMPK and the cancer-metabolism link - ten years after

Hardie, D, Alessi, Dario R

Journal:

Year:

2013

Language:

english

File:

PDF, 1.21 MB

english, 2013

7

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

García-Martínez, Juan M., Alessi, Dario R.

Journal:

Biochemical Journal

Year:

2008

Language:

english

File:

PDF, 977 KB

english, 2008

8

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

Zeqiraj, Elton, Filippi, Beatrice Maria, Goldie, Simon, Navratilova, Iva, Boudeau, Jérôme, Deak, Maria, Alessi, Dario R., van Aalten, Daan M. F., Herschlag, Daniel

Journal:

Year:

2009

Language:

english

File:

PDF, 3.22 MB

english, 2009

9

Cerebellar and Motor Cortical Transcranial Stimulation Decrease Levodopa-Induced Dyskinesias in Parkinson’s Disease

Ferrucci, Roberta, Cortese, Francesca, Bianchi, Marta, Pittera, Dario, Turrone, Rosanna, Bocci, Tommaso, Borroni, Barbara, Vergari, Maurizio, Cogiamanian, Filippo, Ardolino, Gianluca, Di Fonzo, Alessi

Journal:

Year:

2016

Language:

english

File:

PDF, 351 KB

english, 2016

10

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

Pearce, Laura R., Alton, Gordon R., Richter, Daniel T., Kath, John C., Lingardo, Laura, Chapman, Justin, Hwang, Catherine, Alessi, Dario R.

Journal:

Biochemical Journal

Year:

2010

Language:

english

File:

PDF, 787 KB

english, 2010

11

PP1 Phosphatase Complexes: Undruggable No Longer

Vagnarelli, Paola, Alessi, Dario R.

Journal:

Year:

2018

Language:

english

File:

PDF, 424 KB

english, 2018

12

High-Content Peptide Microarrays for Deciphering Kinase Specificity and Biology

Mike Schutkowski, Ulf Reimer, Sören Panse, Liying Dong, Jose M. Lizcano, Dario R. Alessi, Jens Schneider-Mergener

Journal:

Angewandte Chemie

Year:

2004

Language:

english

File:

PDF, 245 KB

english, 2004

13

High-Content Peptide Microarrays for Deciphering Kinase Specificity and Biology

Mike Schutkowski, Ulf Reimer, Sören Panse, Liying Dong, Jose M. Lizcano, Dario R. Alessi, Jens Schneider-Mergener

Journal:

Angewandte Chemie International Edition

Year:

2004

Language:

english

File:

PDF, 245 KB

english, 2004

14

ChemInform Abstract: Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases

Nick R. Leslie, Ricardo M. Biondi, Dario R. Alessi

Journal:

Year:

2001

File:

PDF, 24 KB

2001

15

Small-Molecule Inhibitors of PDK1

Christian Peifer, Dario R. Alessi

Journal:

Year:

2008

Language:

english

File:

PDF, 2.01 MB

english, 2008

16

A meeting of minds: Overcoming roadblocks in the development of therapies for neurodegenerative disorders

Miratul M. K. Muqit, Dario R. Alessi

Journal:

EMBO Molecular Medicine

Year:

2009

Language:

english

File:

PDF, 108 KB

english, 2009

17

Role of the WNK-activated SPAK kinase in regulating blood pressure

Fatema H. Rafiqi, Annie Mercier Zuber, Mark Glover, Ciaran Richardson, Stewart Fleming, Sofija Jovanović, Aleksandar Jovanović, Kevin M. O'Shaughnessy, Dario R. Alessi

Journal:

EMBO Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 738 KB

english, 2010

18

Selective occlusion of tumor blood vessels by targeted delivery of an antibody-photosensitizer conjugate

Monica Fabbrini, Eveline Trachsel, Patrizia Soldani, Stefano Bindi, Patrizia Alessi, Luisa Bracci, Hartwig Kosmehl, Luciano Zardi, Dario Neri, Paolo Neri

Journal:

International Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 475 KB

english, 2006

19

Mechanism and activation and function of protein kinase B

Journal:

Year:

2000

Language:

english

File:

PDF, 95 KB

english, 2000

20

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1 : Potential involvement of Src kinase

Sophie Grillo, Thierry Grémeaux, Antonio Casamayor, Dario R Alessi, Yannick Le Marchand-Brustel, Jean-François Tanti

Journal:

Year:

2000

Language:

english

File:

PDF, 451 KB

english, 2000

21

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells

Alfonso Mora, Guadalupe Sabio, Rosa A. González-Polo, Ana Cuenda, Dario R. Alessi, Juan C. Alonso, José M. Fuentes, Germán Soler, Francisco Centeno

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 595 KB

english, 2001

22

Structure of the OSR1 kinase, a hypertension drug target

Fabrizio Villa, Maria Deak, Dario R. Alessi, Daan M. F. van Aalten

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2008

Language:

english

File:

PDF, 306 KB

english, 2008

23

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, Darren A. E., Alessi, Dario R., Cohen, Philip, Andjelkovich, Mirjana, Hemmings, Brian A.

Journal:

Year:

1995

File:

PDF, 959 KB

1995

24

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Filippi, Beatrice M, de los Heros, Paola, Mehellou, Youcef, Navratilova, Iva, Gourlay, Robert, Deak, Maria, Plater, Lorna, Toth, Rachel, Zeqiraj, Elton, Alessi, Dario R

Journal:

The EMBO Journal

Year:

2011

Language:

english

File:

PDF, 740 KB

english, 2011

25

TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

McManus, Edward J., Alessi, Dario R.

Journal:

Nature Cell Biology

Year:

2002

Language:

english

File:

PDF, 78 KB

english, 2002

26

FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P

Godi, Anna, Campli, Antonella Di, Konstantakopoulos, Athanasios, Tullio, Giuseppe Di, Alessi, Dario R., Kular, Gursant S., Daniele, Tiziana, Marra, Pierfrancesco, Lucocq, John M., Matteis, M. Antoniet

Journal:

Nature Cell Biology

Year:

2004

Language:

english

File:

PDF, 1.75 MB

english, 2004

27

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

Deng, Xianming, Dzamko, Nicolas, Prescott, Alan, Davies, Paul, Liu, Qingsong, Yang, Qingkai, Lee, Jiing-Dwan, Patricelli, Matthew P, Nomanbhoy, Tyzoon K, Alessi, Dario R

Journal:

Nature Chemical Biology

Year:

2011

Language:

english

File:

PDF, 431 KB

english, 2011

28

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

Hinton, Heather J, Alessi, Dario R, Cantrell, Doreen A

Journal:

Nature Immunology

Year:

2004

Language:

english

File:

PDF, 753 KB

english, 2004

29

Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor

Milburn, Christine C, Boudeau, Jérôme, Deak, Maria, Alessi, Dario R, van Aalten, Daan M F

Journal:

Nature Structural and Molecular Biology

Year:

2004

Language:

english

File:

PDF, 1.44 MB

english, 2004

30

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

McManus, Edward J, Collins, Barry J, Ashby, Peter R, Prescott, Alan R, Murray-Tait, Victoria, Armit, Laura J, Arthur, J Simon C, Alessi, Dario R

Journal:

The EMBO Journal

Year:

2004

Language:

english

File:

PDF, 569 KB

english, 2004

31

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

Safrany, Stephen T, Alessi, Dario R, van Aalten, Daan M F, Komander, David, Fairservice, Alison, Deak, Maria, Kular, Gursant S, Prescott, Alan R, Peter Downes, C

Journal:

The EMBO Journal

Year:

2004

Language:

english

File:

PDF, 550 KB

english, 2004

32

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

McManus, Edward J, Sakamoto, Kei, Armit, Laura J, Ronaldson, Leah, Shpiro, Natalia, Marquez, Rodolfo, Alessi, Dario R

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 698 KB

english, 2005

33

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

Sakamoto, Kei, McCarthy, Afshan, Smith, Darrin, Green, Kevin A, Grahame Hardie, D, Ashworth, Alan, Alessi, Dario R

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 508 KB

english, 2005

34

Structural insights into the recognition of substrates and activators by the OSR1 kinase

Villa, Fabrizio, Goebel, Jürgen, Rafiqi, Fatema H, Deak, Maria, Thastrup, Jacob, Alessi, Dario R, van Aalten, Daan M F

Journal:

Year:

2007

Language:

english

File:

PDF, 309 KB

english, 2007

35

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

Biondi, Ricardo M., Cheung, Peter C.F., Casamayor, Antonio, Deak, Maria, Currie, Richard A., Alessi, Dario R.

Journal:

The EMBO Journal

Year:

2000

Language:

english

File:

PDF, 762 KB

english, 2000

36

Brain Penetrant LRRK2 Inhibitor

Choi, Hwan Geun, Zhang, Jinwei, Deng, Xianming, Hatcher, John M., Patricelli, Matthew P., Zhao, Zheng, Alessi, Dario R., Gray, Nathanael S.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.80 MB

english, 2012

37

PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12

Gan, Xiaoqing, Wang, Jiyong, Wang, Chen, Sommer, Eeva, Kozasa, Tohru, Srinivasula, Srinivasa, Alessi, Dario, Offermanns, Stefan, Simon, Melvin I., Wu, Dianqing

Journal:

Nature Cell Biology

Year:

2012

Language:

english

File:

PDF, 3.59 MB

english, 2012

38

Molecular targeting of angiogenesis

Patrizia Alessi, Christina Ebbinghaus, Dario Neri

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Year:

2004

Language:

english

File:

PDF, 272 KB

english, 2004

39

Characterization of TAE684 as a potent LRRK2 kinase inhibitor

Jinwei Zhang, Xianming Deng, Hwan Geun Choi, Dario R. Alessi, Nathanael S. Gray

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.02 MB

english, 2012

40

Hypomorphic Mutation of PDK1 Suppresses Tumorigenesis in PTEN+/− Mice

Jose R. Bayascas, Nick R. Leslie, Ramon Parsons, Stewart Fleming, Dario R. Alessi

Journal:

Current Biology

Year:

2005

Language:

english

File:

PDF, 629 KB

english, 2005

41

Interactions of LY333531 and Other Bisindolyl Maleimide Inhibitors with PDK1

David Komander, Gursant S. Kular, Alexander W. Schüttelkopf, Maria Deak, K.R.C. Prakash, Jennifer Bain, Matthew Elliott, Marta Garrido-Franco, Alan P. Kozikowski, Dario R. Alessi, Daan M.F. van Aalten

Journal:

Year:

2004

Language:

english

File:

PDF, 651 KB

english, 2004

42

Emerging roles of pseudokinases

Jérôme Boudeau, Diego Miranda-Saavedra, Geoffrey J. Barton, Dario R. Alessi

Journal:

Trends in Cell Biology

Year:

2006

Language:

english

File:

PDF, 3.17 MB

english, 2006

43

A minimal cytoplasmic subdomain of the erythropoietin receptor mediates p70 S6 kinase phosphorylation

Min-Ying Zhang, Dwayne L Barber, Dario R Alessi, Laurie L Bell, Carol Stine, Melody H.-H Nguyen, Bryan K Beattie, Joseph Y Cheung, Barbara A Miller

Journal:

Experimental Hematology

Year:

2001

Language:

english

File:

PDF, 727 KB

english, 2001

44

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

Michayla R. Williams, J.Simon C. Arthur, Anudharan Balendran, Jeroen van der Kaay, Valeria Poli, Philip Cohen, Dario R. Alessi

Journal:

Current Biology

Year:

2000

Language:

english

File:

PDF, 362 KB

english, 2000

45

The insulin signalling pathway

Jose M. Lizcano, Dario R. Alessi

Journal:

Current Biology

Year:

2002

Language:

english

File:

PDF, 1.55 MB

english, 2002

46

High-Resolution Structure of the Pleckstrin Homology Domain of Protein Kinase B/Akt Bound to Phosphatidylinositol (3,4,5)-Trisphosphate

Christine C Thomas, Maria Deak, Dario R Alessi, Daan M.F van Aalten

Journal:

Current Biology

Year:

2002

Language:

english

File:

PDF, 389 KB

english, 2002

47

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Dario R. Alessi, Stephen R. James, C.Peter Downes, Andrew B. Holmes, Piers R.J. Gaffney, Colin B. Reese, Philip Cohen

Journal:

Current Biology

Year:

1997

Language:

english

File:

PDF, 172 KB

english, 1997

48

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Dario R. Alessi, Maria Deak, Antonio Casamayor, F. Barry Caudwell, Nick Morrice, David G. Norman, Piers Gaffney, Colin B. Reese, Colin N. MacDougall, Diane Harbison, Alan Ashworth, Mary Bownes

Journal:

Current Biology

Year:

1997

Language:

english

File:

PDF, 671 KB

english, 1997

49

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

Dario R. Alessi, Nestor Gomez, Greg Moorhead, Tom Lewis, Stephen M. Keyse, Philip Cohen

Journal:

Current Biology

Year:

1995

Language:

english

File:

PDF, 2.18 MB

english, 1995

50

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

Dario R. Alessi, Mark T. Kozlowski, Qing-Ping Weng, Nick Morrice, Joseph Avruch

Journal:

Current Biology

Year:

1998

Language:

english

File:

PDF, 171 KB

english, 1998